General Mechanochem Reads

Below is a list of publications that would be good reading for those interested in mechanochemistry. This is not a comprehensive list but more of a starting point. Keep your eyes peeled to RSC Mechanochemistry for more focused mechanochemistry papers. Happy Reading!

Silent Partners in the Mill: Unveiling the Role of Additives in Mechanochemical Synthesis

Briensperger, J.; Podlesnik, N.; Mele, F.; Schnürch, M.; Chem. Eur. J., 2026, e03536.

Mechanochemistry: Looking Back and Ahead

Stolar, F.; Alić, J.; Casali, L.; Gugin, N.; Baláz, M.; Michalchuk, A. A. L.; Emmerling, F.; Chem, 2026, 102880.

Easier, Safer, and Greener: Unlocking the Power of Solid Reagents in Organic Reactions by Mechanochemistry

Gallego, A.; Pétry, N.; Pinaud, J.; Giani, O.; Lamaty, F.; ChemistryEurope, 2025, e202500232.

Conquering the impossible: mechanochemistry as a tool for tackling coordination chemistry challenges

Zhang, H.; Davison, N.; Lu, E.; RSC Mechanochemistry, 2025, 2, 370-388.

Ball Milling for Mechanochemical Reactions

Speight, I. R.; Ardilla-Fierro, K. J.; Hernandez, F. G.; Emmerling, F.; Michalchuk, A. A. L.; Garcia, F.; Colacino, E.; Mack, J.; Nat. Rev. Methods Primer, 2025, 5, 29.

Synthesis without Solvent: Consequences for Mechanochemical Reactivity

Wegner, L., Hanusa, T. P.; Chem. Commun., 2023, 59, 14210-14222.

Safety Considerations and Proposed Workflow for Laboratory-Scale Chemical Synthesis by Ball Milling

Priestly, I.*, Battilocchio, C., Iosub, A. V., Barreteau, F., Bluck, G. W., Ling, K. B., Ingram, K., Ciaccia, M., Leitch, J. A., Browne, D. L.*; Org. Process Res. Dev., 2023, 27, 269-275.

Continuous flow mechanochemistry: reactive extrusion as an enabling technology in organic synthesis

Bolt, R. R. A., Leitch, J. A.*, Jones, A. C., Nicholson, W. I., Browne, D. L.*; Chem. Soc. Rev., 2022, 51, 4243-4260.

Chemistry 2.0: Developing a New, Solvent-Free System of Chemical Synthesis Based on Mechanochemistry

Do, J.-L., Friščić, T.*; Synlett, 2017, 28, 2066-2092. 

Mechanochemistry and organic synthesis: from mystical to practical

Andersen, J., Mack. J.*; Green Chem., 2018, 20, 1435-1443. 

Metal-Mediated and Metal-Catalyzed Reactions Under Mechanochemical Conditions

Porcheddu, A.*, Colacino, E., De Luca, L., Delogu, F., ACS Catal. 2020, 10, 8344-8394.

Mechanochemistry: New Tools to Navigate the Uncharted Territory of "Impossible" Reactions

Cuccu, F., De Luca, L., Delogu, F., Colacino, E., Solin, N., Mocci, R., Porcheddu, A.*, ChemSusChem, 2022, 15, e202200362. 

Altering Product Selectivity by Mechanochemistry

Hernández, J. G.*, Bolm, C.*; J. Org. Chem., 2017, 82, 8, 4007-4019.

Mechanochemistry of Gaseous Reactants

Bolm, C., Hernández, J. G.*; Angew. Chem. Int. Ed., 2019, 58, 11, 3285-3299.

Direct Mechanocatalysis: Using Milling Balls as Catalysts

Pickhardt, W., Grätz, S., Borchardt, L.*; Chem. Eur. J., 2020, 26, 57, 12903-12911.

A guide to direct mechanocatalysis

Hwang, S., Grätz, S., Borchardt, L.*; Chem. Commun., 2022, 58, 1661-1667. 

Advances in organometallic synthesis with mechanochemical methods

Rightmire, N. R., Hanusa, T. P.*; Dalton Trans., 2016, 45, 2352-2362.

Shaking Things from the Ground-Up: A Systematic Overview of the Mechanochemistry of Hard and High-Melting Inorganic Materials

Auvray, T., Friščić, T.*; Molecules, 2023, 28(2), 897.

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